Energy efficiency improvement is an important way to reduce these costs and to increase predictable earnings, especially in times of high energy price volatility. There are a variety of opportunities available at individual plants in the pharmaceutical industry to reduce energy consumption in a cost-effective manner .Heating, ventilation, and air conditioning (HVAC) is typically the most important energy end use in the pharmaceutical industry. Proper utilization of HVAC will save the energy consumption and reduce the production cost.